Diagnostic accuracy of procalcitonin in critically ill immunocompromised patients

摘要: Recognizing infection is crucial in immunocompromised patients with organ dysfunction. Our objective was to assess the diagnostic accuracy of procalcitonin (PCT) critically ill patients. This prospective, observational study included suspected sepsis. Patients were classified into one three groups: no infection, bacterial sepsis, and nonbacterial We 119 a median age 54 years (interquartile range [IQR], 42-68 years). The general severity (SAPSII) dysfunction (LOD) scores on day 1 45 (35-62.7) 4 (2-6), respectively, overall hospital mortality 32.8%. Causes immunodepression hematological disorders (64 patients, 53.8%), HIV (31 26%), solid cancers (26 21.8%). Bacterial sepsis diagnosed 58 infections nine (7.6%); 52 (43.7%) had infection. PCT concentrations first ICU higher group (4.42 [1.60-22.14] vs. 0.26 [0.09-1.26] ng/ml without P 0.5 100% sensitivity but only 63% specificity for diagnosing area under receiver operating characteristic (ROC) curve 0.851 (0.78-0.92). In multivariate analyses, > independently predicted (odds ratio, 8.6; 95% confidence interval, 2.53-29.3; = 0.0006). not significantly correlated mortality. Despite limited may help rule out