Beta-lactam/aminoglycoside combinations: interactions and their mechanisms.

作者: Eliopoulos Gm , Moellering Rc , Allan Jd

DOI:

关键词: PharmacologyBlood Bactericidal ActivityMedicineBacteriaDrug synergismAminoglycosideAntagonismBeta-lactamDrug AntagonismPharmacotherapy

摘要: Combinations of beta-lactams with aminoglycosides are widely used in the therapy infections. There a number theoretic advantages to using such combinations. Indeed, combinations and usually result synergism or indifference very rarely antagonism. The mechanisms synergism, resistance antagonism have been studied extensively enterococci; further studies necessary define other organisms.

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