Hypoxia acclimation and subsequent reoxygenation partially prevent Mn-induced damage in silver catfish

摘要: Abstract This study investigated if hypoxia acclimation modifies the hematological and oxidative profiles in tissues of Mn-exposed silver catfish ( Rhamdia quelen ), such modifications persist upon subsequent reoxygenation. Silver acclimated to (~ 3 mg L − 1 ) for 10 days subsequently exposed Mn (~ 8.1 mg L additional exhibited lower accumulation plasma, liver kidney, even after reoxygenation, as compared normoxia-acclimated fish. Hypoxia increased per se red blood cells count hematocrit, suggesting adaptations under hypoxia, while reoxygenation process was also related hematocrit hemoglobin . Fish normoxia 20 days showed decreased count. prevented Mn-induced damage, observed by reactive species generation higher protein carbonyl levels both kidney normoxia. fish plasma transaminases relation group. Moreover, reduced glutathione levels, catalase activity Na + /K -ATPase during exposure, remaining These findings show that previous generates physiological adjustments, which drive coordinated responses ameliorate antioxidant status Such represent a regulation this teleost against oxygen restriction and/or toxicity order preserve stability particular tissue or system.