Design of membrane targeting tobramycin-based cationic amphiphiles with reduced hemolytic activity
作者： Ido M. Herzog , Mark Feldman , Anat Eldar-Boock , Ronit Satchi-Fainaro , Micha Fridman
DOI: 10.1039/C2MD20162C
关键词: Potency 、 Biochemistry 、 Tobramycin 、 Antimicrobial 、 Chemistry 、 Combinatorial chemistry 、 Membrane 、 Molecule 、 Hemolysis 、 Cationic polymerization 、 Amphiphile 、 Pharmaceutical Science
摘要: Hemolysis caused by amphiphilic tobramycin antimicrobial agents is significantly reduced by altering the bond linking their hydrophobic and hydrophilic parts.
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