Synthesis, structure–activity relationship, and mechanistic investigation of lithocholic acid amphiphiles for colon cancer therapy
作者： Manish Singh , Sandhya Bansal , Somanath Kundu , Priyanshu Bhargava , Ashima Singh
DOI: 10.1039/C4MD00223G
关键词:
摘要: … We report a structure–activity relationship of lithocholic acid amphiphiles for their anticancer activities … of bile acids. Clinical studies have revealed elevated levels of fecal secondary …
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sci-hub.se 参考文章(36)
Uday Maitra, Samrat Mukhopadhyay, Chemistry and biology of bile acids Current Science. ,vol. 87, pp. 1666- 1683 ,(2004)
Jürgen Schölmerich, Frank-Peter Wachs, Gerhard Rogler, Frank Kullmann, René Christian Krieg, Klaus Schlottmann, Characterization of Bile Salt-induced Apoptosis in Colon Cancer Cell Lines Cancer Research. ,vol. 60, pp. 4270- 4276 ,(2000)
Aashish Sharma, Somanath Kundu, Amarendar Reddy M, Avinash Bajaj, Aasheesh Srivastava, None, Design and engineering of disulfide crosslinked nanocomplexes of polyamide polyelectrolytes: stability under biorelevant conditions and potent cellular internalization of entrapped model peptide. Macromolecular Bioscience. ,vol. 13, pp. 927- 937 ,(2013) , 10.1002/MABI.201300018
Sandhya Bansal, Manish Singh, Saqib Kidwai, Priyanshu Bhargava, Ashima Singh, Vedagopuram Sreekanth, Ramandeep Singh, Avinash Bajaj, Bile acid amphiphiles with tunable head groups as highly selective antitubercular agents MedChemComm. ,vol. 5, pp. 1761- 1768 ,(2014) , 10.1039/C4MD00303A
Krishnendu Pal, SubrataKumar Pore, Sutapa Sinha, Rajiv Janardhanan, Debabrata Mukhopadhyay, Rajkumar Banerjee, Structure-activity study to develop cationic lipid-conjugated haloperidol derivatives as a new class of anticancer therapeutics. Journal of Medicinal Chemistry. ,vol. 54, pp. 2378- 2390 ,(2011) , 10.1021/JM101530J
Bhupender S Chhikara, Deendayal Mandal, Keykavous Parang, None, Synthesis, Anticancer Activities, and Cellular Uptake Studies of Lipophilic Derivatives of Doxorubicin Succinate Journal of Medicinal Chemistry. ,vol. 55, pp. 1500- 1510 ,(2012) , 10.1021/JM201653U
Ido M. Herzog, Mark Feldman, Anat Eldar-Boock, Ronit Satchi-Fainaro, Micha Fridman, Design of membrane targeting tobramycin-based cationic amphiphiles with reduced hemolytic activity MedChemComm. ,vol. 4, pp. 120- 124 ,(2013) , 10.1039/C2MD20162C
Sumit O Bajaj, Pei Shi, Penny J Beuning, George A O'Doherty, None, Structure activity relationship study of Mezzettiasides natural products and their four new disaccharide analogues for anticancer/antibacterial activity. MedChemComm. ,vol. 5, pp. 1138- 1142 ,(2014) , 10.1039/C4MD00095A
Ashley A. POWELL, Janna M. LaRUE, A.K. BATTA, Jesse D. MARTINEZ, Bile acid hydrophobicity is correlated with induction of apoptosis and/or growth arrest in HCT116 cells. Biochemical Journal. ,vol. 356, pp. 481- 486 ,(2001) , 10.1042/0264-6021:3560481
Chiara Degirolamo, Salvatore Modica, Giuseppe Palasciano, Antonio Moschetta, Bile acids and colon cancer: Solving the puzzle with nuclear receptors Trends in Molecular Medicine. ,vol. 17, pp. 564- 572 ,(2011) , 10.1016/J.MOLMED.2011.05.010