Endothelial cell-fatty acid binding protein 4 promotes angiogenesis: role of stem cell factor/c-kit pathway.
作者： Harun Elmasri , Elisa Ghelfi , Chen-wei Yu , Samantha Traphagen , Manuela Cernadas
DOI: 10.1007/S10456-012-9274-0
关键词: Endothelium 、 mTORC1 、 Cell biology 、 Downregulation and upregulation 、 Angiogenesis 、 Endothelial stem cell 、 Biology 、 Stem cell factor 、 Cell type 、 Signal transduction
摘要: Fatty acid binding protein 4 (FABP4) plays an important role in regulation of glucose and lipid homeostasis as well inflammation through its actions adipocytes macrophages. FABP4 is also expressed a subset endothelial cells, but this cell type not known. We found that FABP4-deficient human umbilical vein cells (HUVECs) demonstrate markedly increased susceptibility to apoptosis decreased migration capillary network formation. Aortic rings from FABP4(-/-) mice demonstrated angiogenic sprouting, which was recovered by reconstitution FABP4. strongly regulated mTORC1 inhibited Rapamycin. modulated activation several signaling pathways HUVECs, including downregulation P38, eNOS, stem factor (SCF)/c-kit signaling. Of these, the SCF/c-kit pathway have major attenuated activity ECs provision exogenous SCF resulted significant recovery proliferation, survival, morphogenesis, aortic ring sprouting. These data unravel novel pro-angiogenic for cell-FABP4 suggest it could be exploited potential target diseases associated with pathological angiogenesis.
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sci-hub.se 参考文章(48)
Andrea König, Selim Corbacioglu, Matthias Ballmaier, Karl Welte, Downregulation of c- kit Expression in Human Endothelial Cells by Inflammatory Stimuli Blood. ,vol. 90, pp. 148- 155 ,(1997) , 10.1182/BLOOD.V90.1.148
Luigi Biancone, Vincenzo Cantaluppi, Debora Duò, Maria Chiara Deregibus, Carlo Torre, Giovanni Camussi, Role of L-Selectin in the Vascular Homing of Peripheral Blood-Derived Endothelial Progenitor Cells Journal of Immunology. ,vol. 173, pp. 5268- 5274 ,(2004) , 10.4049/JIMMUNOL.173.8.5268
Ryuji Yasumatsu, Ozden Altiok, Charaf Benarafa, Chie Yasumatsu, Gulbin Bingol-Karakoc, Eileen Remold-O'Donnell, Sule Cataltepe, SERPINB1 upregulation is associated with in vivo complex formation with neutrophil elastase and cathepsin G in a baboon model of bronchopulmonary dysplasia American Journal of Physiology-lung Cellular and Molecular Physiology. ,vol. 291, ,(2006) , 10.1152/AJPLUNG.00507.2005
Lucy S Brevetti, David S Chang, Gale L Tang, Rajabrata Sarkar, Louis M Messina, Overexpression of endothelial nitric oxide synthase increases skeletal muscle blood flow and oxygenation in severe rat hind limb ischemia. Journal of Vascular Surgery. ,vol. 38, pp. 820- 826 ,(2003) , 10.1016/S0741-5214(03)00555-X
Hans-Peter Gerber, Amy McMurtrey, Joe Kowalski, Minhong Yan, Bruce A. Keyt, Vishva Dixit, Napoleone Ferrara, Vascular Endothelial Growth Factor Regulates Endothelial Cell Survival through the Phosphatidylinositol 3′-Kinase/Akt Signal Transduction Pathway Journal of Biological Chemistry. ,vol. 273, pp. 30336- 30343 ,(1998) , 10.1074/JBC.273.46.30336
Brendan D. Manning, Lewis C. Cantley, AKT/PKB signaling: navigating downstream. Cell. ,vol. 129, pp. 1261- 1274 ,(2007) , 10.1016/J.CELL.2007.06.009
Bennett OV Shum, Charles R Mackay, Cem Z Gorgun, Melinda J Frost, Rakesh K Kumar, Gökhan S Hotamisligil, Michael S Rolph, The adipocyte fatty acid–binding protein aP2 is required in allergic airway inflammation Journal of Clinical Investigation. ,vol. 116, pp. 2183- 2192 ,(2006) , 10.1172/JCI24767
Peter Carmeliet, Rakesh K. Jain, Molecular mechanisms and clinical applications of angiogenesis Nature. ,vol. 473, pp. 298- 307 ,(2011) , 10.1038/NATURE10144
Peter Carmeliet, Angiogenesis in health and disease. Nature Medicine. ,vol. 9, pp. 653- 660 ,(2003) , 10.1038/NM0603-653
A. W. Zimmerman, J. H. Veerkamp, New insights into the structure and function of fatty acid-binding proteins. Cellular and Molecular Life Sciences. ,vol. 59, pp. 1096- 1116 ,(2002) , 10.1007/S00018-002-8490-Y