Fatty Acid-Binding Protein 4 (FABP4): Pathophysiological Insights and Potent Clinical Biomarker of Metabolic and Cardiovascular Diseases.

摘要: Over the past decade, evidences of an integration metabolic and inflammatory pathways, referred to as metaflammation in several aspects syndrome, have been accumulating. Fatty acid-binding protein 4 (FABP4), also known adipocyte FABP (A-FABP) or aP2, is mainly expressed adipocytes macrophages plays important role development insulin resistance atherosclerosis relation metaflammation. Despite lack a typical secretory signal peptide, FABP4 has shown be released from non-classical pathway associated with lipolysis, possibly acting adipokine. Elevation circulating levels obesity, resistance, diabetes mellitus, hypertension, cardiac dysfunction, atherosclerosis, cardiovascular events. Furthermore, ectopic expression function types cells tissues recently demonstrated. Here, we discuss both significant pathophysiological insights its usefulness biomarker diseases.