Prognosis and Clinicopathology of CXCR4 in Colorectal Cancer Patients: a Meta-analysis
作者： Lu-Ning Li , Kai-Tong Jiang , Peng Tan , Ai-Hua Wang , Qing-Yin Kong
DOI: 10.7314/APJCP.2015.16.9.4077
关键词: Hazard ratio 、 Oncology 、 Meta-analysis 、 Colorectal cancer 、 Stage (cooking) 、 Pathology 、 Case-control study 、 Cancer 、 Internal medicine 、 Medicine 、 Odds ratio 、 Cochrane Library
摘要: The chemokine receptor 4 (CXCR4) has been widely used in diagnosis and prognosis of colorectal cancer (CRC). However, there is no current consensus on the impact CXCR4 CRC patients. purpose this study was to evaluate prognostic clinicopathological importance Databases, such as PubMed, Cochrane library, CBM EMBASE updated 2014 were searched include eligible articles. We analysed correlations between expression features overall survival (OS). A total 1, 055 patients from twelve studies included study. pooled odds ratios (ORs) which indicated likely be associated with TNM stage (OR=0.43, CI=0.34-0.55, P<0.00001), lymph node status (OR=2.23, CI=1.23-4.05, P=0.008) vascular invasion (OR=2.21, CI=1.11-4.39, P=0.02). Poor found significantly related overexpression (hazard ratio (HR) 1.36 CI=1.17-1.59, P<0.0001), whereas combined ORs revealed that had correlation gender or differentiation. Based published studies, indicates poor outcome factors.
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