Physiological and Pharmacological Studies of the Internal Anal Sphincter in the Rat
作者： S. Nissan , Y. Vinograd , A. Hadari , P. Merguerian , O. Zamir
DOI: 10.1016/S0022-3468(84)80006-8
关键词: Medicine 、 Reflex 、 Purinergic receptor 、 Cholinergic 、 Contraction (grammar) 、 Apamin 、 Endocrinology 、 Theophylline 、 Internal medicine 、 Adrenergic 、 Internal anal sphincter
摘要: The rectoanal reflex in the rat consists of relaxation followed by contraction internal anal sphincter (IAS). Beta-adrenergic drugs produce prolonged IAS, where α-agonists cause brief contraction. Muscarinic cholinergic contract IAS. ATP and related purines which is blocked theophylline. persists during adregeneric, cholinergic, purinergic block. potassium-blocker apamin prevents induced rectal distension. This suggests that not mediated adrenergic, or transmitters. Blocking potassium conductance was apparently only way to eliminate this reflex.
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