Mapping Functional Alterations in the CNS With [14C]Deoxyglucose

摘要: The advent of the autoradiographic [14C]-2-deoxyglucose technique (Sokoloff et al., 1977) has provided neuroscientists with an enormously potent tool which to investigate functional events within central nervous system. Two simple premises provide conceptual basis for this novel approach. First, energy requirements cerebral tissue are derived almost exclusively from aerobic catabolism glucose (Sokoloff, 1977; Siesjo, 1978). Second, activity any region system is intimately and directly related consumption that (see Kennedy 1975; Sokoloff, 1977). Thus, ability determine rate simultaneously in all neuroanatomically defined regions CNS conscious animals by use 2-deoxyglucose been widely utilized new insight into processes.