Unmet medical needs in lupus nephritis: solutions through evidence-based, personalized medicine.
作者： Hans-Joachim Anders , Marc Weidenbusch , Brad Rovin
DOI: 10.1093/CKJ/SFV072
关键词: Alternative medicine 、 Personalized medicine 、 Medicine 、 Kidney disease 、 Rituximab 、 Pathology 、 Intensive care medicine 、 Lupus nephritis 、 Evidence-based practice 、 Translational research 、 Randomized controlled trial
摘要: Lupus nephritis (LN) remains a kidney disease with significant unmet medical needs despite extensive clinical and translational research over the past decade. These include need to (i) predict individual risk for LN in patient systemic lupus erythematosus, (ii) identify best therapeutic option an patient, (iii) distinguish chronic damage from active immunologic injury, (iv) develop efficient treatments acceptable or no side effects improve design of randomized trials so that effective drugs demonstrate efficacy. This review discusses underlying reasons these options how overcome them future.
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