CHAPTER 60 – Antisense therapy

摘要: This chapter provides an overview of antisense technology, which exploits oligonucleotide analogs (typically 15–20 nucleotides) to bind cognate RNA sequences through Watson–Crick hybridization resulting in the destruction or disablement target RNA. Thus, technology represents a “new pharmacology” that continues advance. Clinical experience with first generation drugs now exceeds several thousand patients, and number studies suggest therapeutic activity. Second dramatically improved properties are available for clinical trials. Antisense has also been automated such it is useful as tool determine gene function, being used biological roles various cytokine related genes. Further, inhibitors cytokines genes progressing evaluations potential.