Physiogenomic analysis of the Puerto Rican population.
作者： Gualberto Ruaño , Jorge Duconge , Andreas Windemuth , Carmen L Cadilla , Mohan Kocherla
DOI: 10.2217/PGS.09.5
关键词: Personalized medicine 、 Geography 、 Cross-sectional study 、 Genetic testing 、 Allele frequency 、 Demography 、 Population genetics 、 Population 、 Genotyping 、 Latin Americans 、 Genetics
摘要: Aims: Admixture in the population of island Puerto Rico is general interest with regards to pharmacogenetics develop comprehensive strategies for personalized healthcare Latin Americans. This research was aimed at determining frequencies SNPs key physiological, pharmacological and biochemical genes infer structure ancestry Rican population. Materials & methods: A noninterventional, cross-sectional, retrospective study design implemented following a controlled, stratified-by-region, random sampling protocol. The sample based on birthrates each region Rico, according 2004 National Birth Registry. Genomic DNA samples from 100 newborns were obtained Newborn Screening Program dried-blood spot cards. Genotyping using physiogenomic array performed 332 196 cardiometabolic neuroendocrine genes. Population examined Bayesian clustering approach as w...
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