25-Hydroxycholesterol Effect on Membrane Structure and Mechanical Properties

作者: Axel Hollmann , Bárbara Gomes , Marco M. Domingues , Nuno C. Santos

DOI: 10.3390/IJMS22052574

关键词: SphingomyelinLipid bilayerCholesterolMembraneBiophysicsChemistryMembrane structureCholesterol homeostasisAtomic force microscopyForce spectroscopy

摘要: … phospholipids, sphingolipids and sterols. Usually, mammalian cell membranes have higher proportions of phospholipids… (the weighted value obtained from the Gaussian fit is 51 ± 5% …

参考文章(42)
Frederic Vigant, Nuno C. Santos, Benhur Lee, Broad-spectrum antivirals against viral fusion Nature Reviews Microbiology. ,vol. 13, pp. 426- 437 ,(2015) , 10.1038/NRMICRO3475
Patrick Lajoie, Ivan R. Nabi, Lipid rafts, caveolae, and their endocytosis. International Review of Cell and Molecular Biology. ,vol. 282, pp. 135- 163 ,(2010) , 10.1016/S1937-6448(10)82003-9
Pablo V Escribá, Xavier Busquets, Jin-ichi Inokuchi, Gábor Balogh, Zsolt Török, Ibolya Horváth, John L Harwood, László Vígh, None, Membrane lipid therapy: Modulation of the cell membrane composition and structure as a molecular base for drug discovery and new disease treatment Progress in Lipid Research. ,vol. 59, pp. 38- 53 ,(2015) , 10.1016/J.PLIPRES.2015.04.003
Jane Ellen Phillips, Yong-Jian Geng, R.Preston Mason, 7-Ketocholesterol forms crystalline domains in model membranes and murine aortic smooth muscle cells Atherosclerosis. ,vol. 159, pp. 125- 135 ,(2001) , 10.1016/S0021-9150(01)00504-4
Jeffrey L. Hutter, John Bechhoefer, Calibration of atomic‐force microscope tips Review of Scientific Instruments. ,vol. 64, pp. 1868- 1873 ,(1993) , 10.1063/1.1143970
Henri G. Franquelim, Diana Gaspar, A. Salomé Veiga, Nuno C. Santos, Miguel A.R.B. Castanho, Decoding distinct membrane interactions of HIV-1 fusion inhibitors using a combined atomic force and fluorescence microscopy approach Biochimica et Biophysica Acta. ,vol. 1828, pp. 1777- 1785 ,(2013) , 10.1016/J.BBAMEM.2013.03.006
L. Chopinet, C. Formosa, M.P. Rols, R.E. Duval, E. Dague, Imaging living cells surface and quantifying its properties at high resolution using AFM in QI™ mode Micron. ,vol. 48, pp. 26- 33 ,(2013) , 10.1016/J.MICRON.2013.02.003
Jared C. Lawrence, David E. Saslowsky, J. Michael Edwardson, Robert M. Henderson, Real-time analysis of the effects of cholesterol on lipid raft behavior using atomic force microscopy. Biophysical Journal. ,vol. 84, pp. 1827- 1832 ,(2003) , 10.1016/S0006-3495(03)74990-X
Karim El Kirat, Sandrine Morandat, Yves F. Dufrêne, Nanoscale analysis of supported lipid bilayers using atomic force microscopy. Biochimica et Biophysica Acta. ,vol. 1798, pp. 750- 765 ,(2010) , 10.1016/J.BBAMEM.2009.07.026