Fine needle aspiration biopsy of hepatocellular carcinoma: diagnostic dilemma at the ends of the spectrum

摘要: A diagnostic dilemma exists at the extreme ends of spectrum in cytodiagnosis hepatocellular carcinoma (HCC). The cytologic features fine needle aspiration biopsies from 30 well- and 16 poorly differentiated HCC were reviewed adjunctive role serum alpha-fetoprotein (AFP), hepatitis B virus (HBV) markers radiologic findings evaluated. Some subtle noted very well include small tumor cell size with increased nuclear/cytoplasmic ratio, monotony atypia, hepatocytic giant cells narrow trabeculae tendency for dissociation. Useful dehiscence, large ovoid nuclei thickened nuclear membranes, one or more increasingly prominent nucleoli, some assuming a reniform configuration. AFP levels are not always elevated. Positive HBV markers, cirrhosis compatible imaging suggestive but diagnostic. general inclination, however, is still toward diagnosis if aspirate focal lesion lesions surface antigen-positive, cirrhotic liver. Cell block sections provide histologic confirmation.