Ultrafast capillary electrophoresis method for the simultaneous determination of ammonium and diphenhydramine in pharmaceutical samples.
作者： Brenda Maria de Castro Costa , Mariana Cardoso Marra , Thiago da Costa Oliveira , Rodrigo Alejandro Abarza Munoz , Alex Domingues Batista
关键词: Lithium hydroxide 、 Detection limit 、 Capillary electrophoresis 、 Kjeldahl method 、 Analyte 、 Chemistry 、 Capillary action 、 Chromatography 、 Ammonium 、 Ethanesulfonic acid
摘要: Ammonium and diphenhydramine are active ingredients commonly found in the same pharmaceutical preparations. We report, for first time, a sub-minute method simultaneous determination of ammonium diphenhydramine. The is based on capillary electrophoresis with capacitively coupled contactless conductivity detection. Both analytes can be quantified single run (∼80 injections/h) using 30 mmol/L 2-(N-morpholino)ethanesulfonic acid 15 lithium hydroxide (pH 6.0) as background electrolyte. separation by was achieved fused-silica (50 cm total length, 10 effective 50 μm inside diameter). limits detection were 0.04 0.02 diphenhydramine, respectively. proposed also provided adequate recovery values spiked samples (100-106 97-104% respectively). results obtained new compared those high-performance liquid chromatography Kjeldahl no statistically significant differences (95% confidence level).
sci-hub.se 参考文章(42)
Coral Barbas, Antonia Garcı́a, Luis Saavedra, Mario Castro, Optimization and validation of a method for the determination of caffeine, 8-chlorotheophylline and diphenhydramine by isocratic high-performance liquid chromatography. Stress test for stability evaluation. Journal of Chromatography A. ,vol. 870, pp. 97- 103 ,(2000) , 10.1016/S0021-9673(99)01186-3
Marko Stojkovic, Israel Joel Koenka, Wolfgang Thormann, Peter C. Hauser, Contactless conductivity detector array for capillary electrophoresis Electrophoresis. ,vol. 35, pp. 482- 486 ,(2014) , 10.1002/ELPS.201300457
Jarbas Jos� Rodrigues Rohwedder, Celio Pasquini, Differential conductimetry in flow injection. Determination of ammonia in Kjeldahl digests Analyst. ,vol. 116, pp. 841- 845 ,(1991) , 10.1039/AN9911600841
Thiago Nogueira, Claudimir Lucio do Lago, Determination of Ca, K, Mg, Na, sulfate, phosphate, formate, acetate, propionate, and glycerol in biodiesel by capillary electrophoresis with capacitively coupled contactless conductivity detection Microchemical Journal. ,vol. 99, pp. 267- 272 ,(2011) , 10.1016/J.MICROC.2011.05.014
Adolfo Francesco Attili, Domenico Autizi, Livio Capocaccia, Sergio Costantini, Fabio Cotta-Ramusino, Rapid determination of plasma ammonia using an ion specific electrode Biochemical Medicine. ,vol. 14, pp. 109- 116 ,(1975) , 10.1016/0006-2944(75)90025-3
Niklas Strömberg, Stefan Hulth, A fluorescence ratiometric detection scheme for ammonium ions based on the solvent sensitive dye MC 540 Sensors and Actuators B: Chemical. ,vol. 90, pp. 308- 318 ,(2003) , 10.1016/S0925-4005(03)00053-4
Roger C.H. Kwan, Phoebe Y.T. Hon, Reinhard Renneberg, Amperometric determination of ammonium with bienzyme/poly(carbamoyl) sulfonate hydrogel-based biosensor Sensors and Actuators B: Chemical. ,vol. 107, pp. 616- 622 ,(2005) , 10.1016/J.SNB.2004.11.028
Mohammed Shahid Ali, Mohsin Ghori, Syed Rafiuddin, Aamer Roshanali Khatri, A new hydrophilic interaction liquid chromatographic (HILIC) procedure for the simultaneous determination of pseudoephedrine hydrochloride (PSH), diphenhydramine hydrochloride (DPH) and dextromethorphan hydrobromide (DXH) in cough-cold formulations. Journal of Pharmaceutical and Biomedical Analysis. ,vol. 43, pp. 158- 167 ,(2007) , 10.1016/J.JPBA.2006.06.038
Antonio Calvo-López, Oriol Ymbern, Mar Puyol, Joan Manel Casalta, Julián Alonso-Chamarro, Potentiometric analytical microsystem based on the integration of a gas-diffusion step for on-line ammonium determination in water recycling processes in manned space missions Analytica Chimica Acta. ,vol. 874, pp. 26- 32 ,(2015) , 10.1016/J.ACA.2014.12.038
P Bertocchi, D Compagnone, G Palleschi, Amperometric ammonium ion and urea determination with enzyme-based probes Biosensors and Bioelectronics. ,vol. 11, pp. 1- 10 ,(1996) , 10.1016/0956-5663(96)83708-0