New Mouse Model for Dengue Virus Vaccine Testing
作者： Alison J. Johnson , John T. Roehrig
DOI: 10.1128/JVI.73.1.783-786.1999
关键词: Virology 、 Immunization 、 Interferon gamma 、 Virus 、 Dengue fever 、 Biology 、 Immunology 、 Polyclonal antibodies 、 Viral Vaccine 、 Dengue virus 、 Interferon
摘要: Several dengue (DEN) virus vaccines are in development; however, the lack of a reliable small animal model which to test them is major obstacle. Because evidence suggests that interferon (IFN) involved human anti-DEN response, we tested mice deficient their IFN functions as potential models. Intraperitoneally administered mouse-adapted DEN 2 was uniformly lethal AG129 (which alpha/beta and gamma receptor genes), regardless age. Immunized were protected from challenge, survival times increased following passive transfer polyclonal antibody. These results demonstrate promising for vaccine trials.
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