Maternal psychological distress and fetal growth trajectories: The Generation R Study

摘要: Background. Previous research suggests, though not consistently, that maternal psychological distress during pregnancy leads to adverse birth outcomes. We investigated whether affects fetal growth the period of mid-pregnancy until birth. Method. Pregnant women (n=6313) reported levels using Brief Symptom Inventory (anxious and depressive symptoms) Family Assessment Device (family stress) at 20.6 weeks had ultrasound measurements in mid- late pregnancy. Estimated weight was calculated head circumference, abdominal circumference femur length. Results. In mid-pregnancy, linked size. pregnancy, however, anxious symptoms were related size after controlling for potential confounders. Anxious also associated with a 37.73 g (95 % confidence interval (CI) x69.22 x6.25, p=0.019) lower weight. When we curves multilevel models, more consistent results emerged. Maternal anxiety or depression impaired gain growth. For example, reduced by 2.86 CI x4.48 x1.23, p<0.001) per week. Conclusions. The study suggests that, starting can be affected different aspects distress. particular, children prenatally mothers seem display patterns Future work should address biological mechanisms underlying association development focus on effects reducing