TH2 cells in the pathogenesis of airway remodeling: regulatory T cells a plausible panacea for asthma.

摘要: T-helper type 2 (TH2) cells are one of the hallmarks airway remodeling. The daunting task regaining tolerance will be to regulate hyperresponsiveness (AHR) and remodeling in chronic asthma by balancing ballet TH1 TH2 cells. mechanism appears modulated a specialized subset T called regulatory (Tregs). Currently there six subtypes Tregs including CD4+CD25+ naturally occurring (N-Tregs), inducible naive CD4+CD25−T (TR1), TR1 memory phenotype, 3 (TH3), CD4−CD25+DX5+ natural killer (TRNKT), CD4−CD25+CD8+ cytotoxic (TRCTC). development is controversial as whether they occur thymus or peripheral lymphoid tissue. Studies have shown that N-Tregs generated periphery. Nevertheless, express an arsenal molecular membrane markers: CD3, CD25, CD62L, CD69, BTLA, GITR, ICOS, Neuroplin-1 (Nrp-1), PD-1. However, most definitive marker Forkhead Winged-Helix Transcriptional Factor Box p3 (Foxp3). suppression occurs cell-to-cell contact, low levels IL-10 moderate TGF-β, but primary involves sequestration activation neighboring become In contrast, exert their suppressive properties copious secretion TGF-β. These mechanisms inhibition IL-2 production promotion cell cycle arrest. this enigma, understanding provide plausible panacea for asthma.