Effects of Tranilast and Pentoxifylline in a Mouse Model of Chronic Asthma Using House Dust Mite Antigen
作者： Seung Joon Kim , Jin Woo Kim , Yong Hyun Kim , Sang Haak Lee , Hyoung Kyu Yoon
DOI: 10.3109/02770900903089998
关键词:
摘要: Tranilast has been used in allergic diseases because of its inhibitory effect on mast cells; it also an anti-fibrotic several diseases. Pentoxifylline (PTX), a methylxanthine derivative, is potent anti-inflammatory drug that known to manifest through the inhibition Th1 cytokine, but with uncertain Th2 cytokine. Seven-week-old female BALB/c mice were studied as chronic asthma model. The challenged house dust mite (HDM) antigen for 7 weeks. Each group was given intraperitoneal injection tranilast, PTX, or tranilast plus PTX before administration. In this mouse model asthma, and each had airway remodeling well hyperresponsiveness (AHR) inflammation. improved events these drugs related cytokine IL-13 TGF-beta 1. Immunohistochemical analysis showed decreases peribronchial trichrome stained area treatment associated improvements smooth muscle hyperplasia, collagen type I, III deposition. These could have potential beneficial effects especially respect remodeling.
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