Interaction between Pazufloxacin and DNA mediated by copper(II) ions.
作者： Guoliang Zhang , Xuchun Fu , Qingwang Liu , Guoping Wang
DOI: 10.1007/S10895-008-0342-1
关键词: Crystallography 、 Stereochemistry 、 Spectrophotometry 、 Pazufloxacin 、 Ion 、 Absorption spectroscopy 、 Ternary numeral system 、 DNA 、 Copper 、 Chemistry 、 Fluorescence
摘要: The influence of copper(II) ions on the binding Pazufloxacin (PFLX), which is a forth generation quinolone antimicrobial agent, to calf thymus DNA (CTDNA) has been investigated by fluorescence, absorption spectroscopy and viscosity measurement. results show that PFLX Cu2+ can form binary complex with mole ratio 2:1, CTDNA mediated Cu2+. A ternary system PFLX–Cu2+–DNA were proposed. experimental binds two kinds modes, intercalative mode groove mode.
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