Dietary L-arginine supplementation increases muscle gain and reduces body fat mass in growing-finishing pigs.

摘要: Obesity in humans is a major public health crisis worldwide. In addition, livestock species exhibit excessive subcutaneous fat at market weight. However, there are currently few means of reducing adiposity mammals. This study was conducted with swine model to test the hypothesis that dietary l-arginine supplementation may increase muscle gain and decrease deposition. Twenty-four 110-day-old barrows were assigned randomly into two treatments, representing 1.0% or 2.05% l-alanine (isonitrogenous control) corn- soybean meal-based diet. Growth performance measured based on weight food intake. After 60-day period supplementation, carcass composition measured. Serum triglyceride concentration 20% lower (P < 0.01) but glucagon level 36% greater 0.05) arginine-supplemented than control pigs. Compared control, arginine increased body by 6.5% skeletal-muscle content 5.5%, while decreasing 11%. The treatment enhanced longissimus dorsi protein, glycogen, contents 4.8, 42, 70%, respectively, as well pH 45 min post-mortem 0.32, lactate 37%. These results support our beneficially promotes reduces accretion growing-finishing findings have positive impact development novel therapeutics treat human obesity enhance lean-tissue growth.