Bioavailability Algorithms in Setting Recommended Dietary Allowances: Lessons from Iron, Applications to Zinc

摘要: In addition to determining the amounts of isolated nutrients required for physiological function and homeostatic control, setting Recommended Dietary Allowances requires a consideration nutrient bioavailability from foods in common diets. Bioavailability algorithms, or mathematical models estimate different diets, have great appeal help establish recommended intakes identify beneficial dietary modifications. Accurate algorithms are difficult develop because chemical complexity food supply numerous interactions that affect mineral elements. A combination reductionist holistic approaches is necessary effects components, then evaluate these complicated matrix whole diet. The most extensive development has been iron, understanding strengths weaknesses iron may other inorganic such as zinc. Examples provided indicate possible revision difficulty verifying with status indices, zinc algorithms. must be considered context biological control absorption, utilization excretion, which outweigh importance diets affluent countries varied abundant supply. While helpful estimating changes recommendations, improving populations high incidence deficiency mineral, they not yet sufficiently developed validated quantitative recommendations bioavailable intake.