Simultaneous determination of ethamsylate, tramadol and lidocaine in human urine by capillary electrophoresis with electrochemiluminescence detection
作者： Jianguo Li , Huangxian Ju
关键词: Local anesthetic 、 Chromatography 、 Chemistry 、 Ethamsylate 、 Capillary electrophoresis 、 Urine 、 Electrochemiluminescence 、 Tramadol 、 Analgesic 、 Lidocaine
摘要: Ethamsylate, tramadol and lidocaine, partly excreted by the kidney, are generally used as hemostatic, analgesic and local anesthetic in surgery. We developed a simple and sensitive method for their simultaneous monitoring in human urine based on CE coupled with electrochemiluminescence detection by end‐column mode. Under optimized conditions the proposed method yielded linear ranges from 5.0× 10− 8 to 5.0× 10− 5, 1.0× 10− 7 to 1.0× 10− 4 and 1.0× 10− 7 to 1.0× 10− 4 M with LODs of 8.0× 10− 9 M (36 amol), 1.6× 10− 8 M …
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