Age-dependent effects on social interaction of NMDA GluN2A receptor subtype-selective antagonism.

摘要: Abstract NMDA receptor-mediated neurotransmission is implicated in the regulation of normal sociability mice. The heterotetrameric receptor composed two obligatory GluN1 and either “modulatory” GluN2A or GluN2B subunits. GluN2B-containing receptors differ terms their developmental expression, distribution between synaptic extrasynaptic locations, channel kinetic properties, among other differences. Because age-dependent differences disruptive effects subtype-selective antagonists on locomotor activity have been reported rats, current investigation explored PEAQX, a antagonist, sociability, stereotypic behaviors emerging during social interaction, spatial working memory 4- 8-week old male Swiss Webster data implicate an contribution GluN2A-containing to interaction Specifically, at dose PEAQX devoid any effect mouse rotarod performance, mice was disrupted without salience stimulus mouse. Moreover, attenuated behavior However, had no spontaneous alternations, measure memory, suggesting that neural circuits mediating may be discrete dissociable from each other. Also, suggest occur independently expression occurs later stage, they more involved pathogenesis ASDs patients with histories “regression” after period development than receptors.