Biological activity of Anthraquinones and Triterpenoids from Prismatomeris fragrans
作者： Kwanjai Kanokmedhakul , Somdej Kanokmedhakul , Ruchanee Phatchana
DOI: 10.1016/J.JEP.2005.03.018
关键词: Ether 、 Pharmacognosy 、 Stereochemistry 、 Prismatomeris 、 Damnacanthal 、 Biological activity 、 Terpenoid 、 Chemistry 、 Triterpene 、 Anthraquinones
摘要: A new 1,3-dihydroxy-2-methyl-5,6-dimethoxyanthraquinone (1); six known anthraquinones, nordamnacanthal (2), damnacanthal (3), rubiadin (4), rubiadin-1-methyl ether (5), lucidin-omega-methyl (6), and 1-hydroxy-2-hydroxymethyl-3-methoxyanthraquinone (7); a beta-sitosterol (8); together with two triterpenoids, beta-acetylolean-12-en-28-olic acid (9), 3beta-O-acetyl-11alpha,12alpha-epoxyolean-28,13-olide (10) were isolated from the roots stems of Prismatomeris fragrans. Their structures established on basis spectral data. This is first isolation compounds 2, 6, 7, 9 10 genus. The evaluated in antiplasmodial, antituberculosis, antifungal anticancer cell lines tests. bioactivity assays showed that only exhibited moderate antimalarial activity, 2 3 activity while 3, 4, 7 antituberculosis activity. In addition, cytotoxicity to BC line 1, 1a (the methyl derivative 1), 5, NCI-H187 line.
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