Flexible, multichannel cuff electrode for selective electrical stimulation of the mouse trigeminal nerve.
作者： Jihye Bong , Jared P. Ness , Weifeng Zeng , Hyungsoo Kim , Joseph Novello
DOI: 10.1016/J.BIOS.2019.111493
关键词: Somatosensory evoked potential 、 Cuff 、 Electrode 、 Trigeminal nerve 、 Chemistry 、 Adjunctive treatment 、 Cranial nerves 、 In vivo 、 Stimulation 、 Biomedical engineering
摘要: The trigeminal nerve (cranial V), along with other cranial nerves, has in recent years become a popular target for bioelectric medicine due to its direct access neuromodulatory centers. Trigeminal stimulation is currently being evaluated as an adjunctive treatment various neurodegenerative and neuropsychiatric diseases despite the mechanism of action question. In this work, we describe development validation novel neural interface infraorbital branch utilizing thin film (TF) cuff containing multiple electrode sites allowing more selective nerve. We characterized properties device using electrochemical impedance spectroscopy, cyclic voltammetry, voltage excursions, vivo testing. Electrochemical measurements demonstrate that platinum-based electrodes possess capacitive charge carrying suitable biological tissue safe injection limit 73.13 μC/cm2. experiments show TF can reliably stimulate targets eliciting cortical responses similar silicone electrode. Furthermore, selecting different pairs on modulated magnitude and/or spatial pattern suggesting may be able selectively parts These results suggest viable enables future research examining therapeutic mechanisms stimulation.
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