Peroral gene therapy of diabetes and obesity

作者: Matthew John During

DOI:

关键词: ObesityEndocrinologyBiologySystemic circulationImmunologyInsulinSecretionInternal medicineGenetic enhancementDiabetes mellitusEnteroendocrine cellVector (molecular biology)

摘要: The invention provides methods and compositions for targeting endocrine cells capable of converting an immature expressed protein into a mature protein, secreting the systemic circulation. In particular, features treating disorders, such as diabetes by orally administering vector expressing insulin to target which can subsequently secrete blood

参考文章(11)
Ira D. Goldfine, Michael German, Stephen S. Rothman, Delivery of gene products by intestinal cell expression ,(1997)
Stephen S. Rothman, Michael S. German, Ira D. Goldfine, Protein delivery by secretory gland expression ,(1998)
N Zhu, D Liggitt, Y Liu, R Debs, Systemic gene expression after intravenous DNA delivery into adult mice Science. ,vol. 261, pp. 209- 211 ,(1993) , 10.1126/SCIENCE.7687073
Lan Peng, Richard A. Sidner, Markian R. Bochan, Matthew M. Burton, Scott T. Cooper, Rahul M. Jindal, Construction of Recombinant Adeno-Associated Virus Vector Containing the Rat Preproinsulin II Gene☆ Journal of Surgical Research. ,vol. 69, pp. 193- 198 ,(1997) , 10.1006/JSRE.1997.5079
A. Sugiyama, S. Hattori, S. Tanaka, F. Isoda, S. Kleopoulos, M. Rosenfeld, M. Kaplitt, H. Sekihara, C. Mobbs, Defective Adenoassociated Viral-Mediated Transfection of Insulin Gene by Direct Injection into Liver Parenchyma Decrease Blood Glucose of Diabetic Mice Hormone and Metabolic Research. ,vol. 29, pp. 599- 603 ,(1997) , 10.1055/S-2007-979108
Barbara Leibiger, Ingo Leibiger, Dieter Sarrach, Hartmut Zühlke, Expression of exogenous DNA in rat liver cells after liposome-mediated transfection in vivo. Biochemical and Biophysical Research Communications. ,vol. 174, pp. 1223- 1231 ,(1991) , 10.1016/0006-291X(91)91552-N
Stephen S. Rothman, Michael German, Ira D. Goldfine, Intravenous hormone polypeptide delivery by salivary gland expression ,(1995)
Christopher B. Newgard, Fred Kruse, Philippe A. Halban, Christian Quaade, Anice E. Thigpen, Karl D. Normington, Samuel A. Clark, Recombinant expression of proteins from secretory cell lines ,(1997)
M German, Gene therapy by secretory gland expression Biofutur. ,vol. 1997, pp. 44- ,(1996) , 10.1016/S0294-3506(97)89249-6
Mark Leavitt, Michael Mamounas, Mang Yu, Flossie Wong-Staal, Increasing rAAV titer ,(1995)