Insect-specific paralytic neurotoxin genes for use in biological insect control: methods and compositions

作者: Michael D. Tomalski , Lois K. Miller

DOI:

关键词: PyemotesPromoterMicrobiologyBiologyInsectRecombinant DNABiochemistryHeterologousGeneControl methodsNeurotoxin

摘要: Genes encoding insect-specific paralytic neurotoxins, particularly those of insect-parasitic mites, including Pyemotes, are described. Recombinant DNA molecules in which the neurotoxin coding sequences placed under control heterologous promoters also Such useful for development biological insect agents produce insect-toxic levels neurotoxin. Specifically described genetically altered baculoviruses neurotoxins and display improved toxic effect on insects. Insect-toxic compositions provided. Methods using these genes, methods production cells,

参考文章(18)
Russell Doolittle, Of urfs and orfs ,(1986)
Ashwani Sood, Dennis Pereira, Sherman M Weissman, Method for cloning genes ,(1981)
Michal Eitan, Rama M. Belagaje, Elizabeth Fowler, Jean L. Roberts, Eliahu Zlotkin, Oz Ben-Yehuda, Insecticidal toxines, genes coding therefor, antibodies binding them, transgenic plant cells and plants expressing these toxines ,(1989)
K. Maramorosch, Biotechnology, Invertebrate Pathology, and Cell Culture Bulletin of the Entomological Society of America. ,vol. 32, pp. 216- 221 ,(1986) , 10.1093/BESA/32.4.216
Susumu Maeda, Increased insecticidal effect by a recombinant baculovirus carrying a synthetic diuretic hormone gene Biochemical and Biophysical Research Communications. ,vol. 165, pp. 1177- 1183 ,(1989) , 10.1016/0006-291X(89)92726-5
Martin R. Hodge, Michael D. Tomalski, Lois K. Miller, Luis F. Carbonell, Synthesis of a gene coding for an insect-specific scorpion neurotoxin and attempts to express it using baculovirus vectors. Gene. ,vol. 73, pp. 409- 418 ,(1988) , 10.1016/0378-1119(88)90505-7
E. Zlotkin, D. Kadouri, D. Gordon, M. Pelhate, M.F. Martin, H. Rochat, An excitatory and a depressant insect toxin from scorpion venom both affect sodium conductance and possess a common binding site Archives of Biochemistry and Biophysics. ,vol. 240, pp. 877- 887 ,(1985) , 10.1016/0003-9861(85)90098-0