Genetic study of breast cancer: Identification of a high risk group

摘要: A group of women was identified whose risk for breast cancer 47-to 51-fold higher than that experienced by control women. These high-risk were sisters patients mothers had cancer. The disease in these families developed premenopausally, often bilaterally, and seemingly associated with ovarian function. Since susceptibility transmitted from an affected mother to approximately 30% her daughters, this early, bilateral form appeared be strongly heritable. Another, less heritable comprised at least two unaffected mothers. 3-fold controls, the primarily postmenopausal, unilateral, not No difference observed transmission through paternal maternal lines descent.