Maternal and neonatal leptin and leptin receptor polymorphisms associated with preterm birth
作者： Hagit Salem , Talya Rosenfeld , Gheona Altarescu , Sorina Grisaru-Granovsky , Ruth Birk
DOI: 10.1016/J.GENE.2016.07.014
关键词: Pregnancy 、 Single-nucleotide polymorphism 、 Endocrinology 、 Allele frequency 、 Leptin 、 Biology 、 Internal medicine 、 Premature birth 、 Restriction fragment length polymorphism 、 Leptin receptor 、 Genotype 、 Genetics 、 General Medicine
摘要: Abstract Leptin ( LEP ) and leptin receptor LEPR are suggested to play a role in female reproduction especially pregnancy Both synthesized by the pregnant embryo. The link between genetic polymorphisms of preterm birth (PTB) is unknown. We studied maternal neonatal association with PTB. Blood for DNA analysis was collected from Israeli mothers venous umbilical their respected idiopathic newborns (24–36 weeks, n = 102) control term (> 37 weeks, n = 158). Genotypes (rs7799039) (rs1137101) were analyzed restriction fragment length polymorphism analysis. Genotype-phenotype assayed using SPSS program. found significant independent increased risk PTB women neonates bearing homozygous AA form genotype; where carrying genotype had 2.53 fold ([CI] 1.367–4.685, p = 0.03) 2.38 1.150–4.915, p = 0.019) compared AG GG genotypes, respectively. Neonates 2.8 (CI11.040–7.577, p = 0.042). Maternal significantly associated severe PTB; genotypes 4.32 4.76 (CI = 1.090–17.112 1.332–17.027, respectively p = 0.035). In conclusion:
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