Interleukin-17 and leptin genes polymorphisms and their levels in relation to recurrent pregnancy loss in Egyptian females.
作者： Haidy E. Zidan , Noha A. Rezk , Amr Abd Almohsen Alnemr , Mohamed I. Abdel Moniem
DOI: 10.1007/S00251-015-0876-8
关键词: Restriction fragment length polymorphism 、 Obesity 、 SNP 、 Biology 、 Case-control study 、 Polymorphism (computer science) 、 Endocrinology 、 Internal medicine 、 Leptin 、 Real-time polymerase chain reaction 、 Pregnancy
摘要: Recurrent pregnancy loss (RPL) is a common problem during early gestation. The aim of our study was to investigate the association IL-17 F( rs763780), A (rs2275913), and leptin (2548 G/A) gene polymorphisms with RPL in obese lean Egyptian females, find out whether these affect women’s serum levels. One hundred twenty patients 120 fertile volunteers no history were genotyped for G/A), F (rs763780) by RFLP. level measured ELISA, while HPLC. We found that polymorphism associated decreased risk we also (rs2275913) LEP SNP an increased RPL. demonstrated both levels elevated women subgroup within comparison one.
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