Incidence and persistence of carcinogenic genital human papillomavirus infections in young women with or without Chlamydia trachomatis co-infection.

摘要: We assessed whether infection with chlamydia increases the incidence of carcinogenic human papillomavirus (HPV) infections and if HPV persistence is affected by co-infection. For 1982 women (16–29 years-old) participating in two consecutive rounds a screening implementation trial, swabs were polymerase chain reaction tested to detect 14 genotypes. type-specific rates stratified for positivity at follow-up. Associations multilevel logistic regression analyses correction sexual risk factors. ranged from 1.4% 8.9% 22.7% 59.4% after median follow-up 11 months (interquartile range: 11–12). Differences 1-year between -infected noninfected less distinct than differences (pooled adjusted odds ratios 1.17 [95% CI: 0.69–1.96] 1.84 1.36–2.47], respectively). The effect co-infection on HPV-infection did not significantly differ genotype. In conclusion, types may enhance some types. Although these findings could reflect residual confounding through unobserved factors, our results do give reason explore more fully association acquisition persistence.