Blood-arachnoid barrier disruption in experimental rat meningitis detected using gadolinium-enhancement ratio imaging.
作者： Hiroyuki Ichikawa , Kouichi Itoh
DOI: 10.1016/J.BRAINRES.2011.03.035
关键词: Interleukin 、 Central nervous system 、 Lipopolysaccharide 、 Pathology 、 Cytokine 、 Pathophysiology 、 Central nervous system disease 、 Magnetic resonance imaging 、 Meningitis 、 Immunology 、 Medicine
摘要: Disruption of the central nervous system (CNS) barriers is one major pathophysiological consequences bacterial meningitis. The increase in permeability CNS caused by disruption thought to contribute development adverse neurological outcomes. We have established a method which barrier can be demonstrated gadolinium-enhancement ratio (GER) calculated from T₁ weighted image (T₁WI) based on gadolinium-enhanced magnetic resonance imaging (GdEMRI). present study examined such as blood-brain (BBB), blood-cerebrospinal fluid (BCSFB) and blood-arachnoid (BAB) rats with meningitis induced lipopolysaccharide (LPS)- or interleukin (IL)-1β. Four hours after intracisternal injection LPS IL-1β, severe BAB, but not BBB BCSFB, was observed. This suggests that rather than plays key role influx blood-borne cells substances during BAB therefore more vulnerable BCSFB rats. In addition, GdEMRI GER analysis appears useful spatio-temporal studies function under various physiological pathological conditions.
elsevier.com
bunri-u.ac.jp 
researchgate.net 参考文章(34)
Tunkel Ar, Wispelwey B, Scheld Wm, Pathogenesis and pathophysiology of meningitis. Infectious Disease Clinics of North America. ,vol. 4, pp. 555- 581 ,(1990) , 10.1016/S0891-5520(20)30366-4
R L Friede, W Schachenmayr, The origin ofsubdural neomembranes. II. Fine structural of neomembranes. American Journal of Pathology. ,vol. 92, pp. 69- 84 ,(1978)
Sanford L. Palay, Alan Peters, Henry deF Webster, The fine structure of the nervous system : neurons and their supporting cells ,(1991)
Ivo Lambrichts, Julia Creemers, Frank Vandenabeele, Ultrastructure of the human spinal arachnoid mater and dura mater. Journal of Anatomy. ,vol. 189, pp. 417- 430 ,(1996)
A R Tunkel, W M Scheld, Pathogenesis and pathophysiology of bacterial meningitis. Clinical Microbiology Reviews. ,vol. 6, pp. 118- 136 ,(1993) , 10.1128/CMR.6.2.118
Mahmoud M. Mustafa, Cerebrospinal Fluid Prostaglandins, Interleukin 1β, and Tumor Necrosis Factor in Bacterial Meningitis American Journal of Diseases of Children. ,vol. 144, pp. 883- 887 ,(1990) , 10.1001/ARCHPEDI.1990.02150320047024
C. P. HAWKINS, P. M. G. MUNRO, F. MACKENZIE, J. KESSELRING, P. S. TOFTS, E. P. G. H. DU BOULAY, D. N. LANDON, W. I. McDONALD, Duration and selectivity of blood-brain barrier breakdown in chronic relapsing experimental allergic encephalomyelitis studied by gadolinium-DTPA and protein markers. Brain. ,vol. 113, pp. 365- 378 ,(1990) , 10.1093/BRAIN/113.2.365
Marcelo Gottschalk, Mariela Segura, The pathogenesis of the meningitis caused by Streptococcus suis: the unresolved questions. Veterinary Microbiology. ,vol. 76, pp. 259- 272 ,(2000) , 10.1016/S0378-1135(00)00250-9
Hiroyuki Ichikawa, Makoto Ishikawa, Mari Fukunaga, Koichi Ishikawa, Hironobu Ishiyama, Quantitative evaluation of blood-cerebrospinal fluid barrier permeability in the rat with experimental meningitis using magnetic resonance imaging Brain Research. ,vol. 1321, pp. 125- 132 ,(2010) , 10.1016/J.BRAINRES.2010.01.050
Stephen L. Leib, Martin G. Täuber, PATHOGENESIS OF BACTERIAL MENINGITIS Infectious Disease Clinics of North America. ,vol. 13, pp. 527- 548 ,(1999) , 10.1016/S0891-5520(05)70093-3