Role of 5-HT3 receptors and afferent fibers in the effects of mast cell degranulation on colonic motility in rats
作者： Nathalie Castex , Jean Fioramonti , Marie JoséFargeas , Jean More , Lionel Bueno
DOI: 10.1016/0016-5085(94)90221-6
关键词: Ketotifen 、 Calcitonin gene-related peptide 、 Receptor 、 Chemistry 、 Substance P 、 Degranulation 、 Internal medicine 、 Endocrinology 、 Mast cell stabilizer 、 Serotonin 、 Capsaicin
摘要: Abstract Background/Aims: Mediators released by mast cell degranulation contribute to digestive motility disturbances. According the role of serotonin and close proximity cells nerves, aim this study was assess 5-hydroxytryptamine 3 (5-HT ) receptors, capsaicin-sensitive afferent fibers, some their neuropeptides (substance P calcitonin gene-related peptide) in colonic motor alterations induced compound BrX-537A. Methods: The effects BrX-537A (2 mg/kg intraperitoneally) were determined electromyography conscious rats implanted with electrodes cecocolonic wall. Results: inhibited myoelectric activity for 7–8 hours. A primary dramatic reduction spike burst frequency, lasting 30 minutes, affected none pretreatments tested. following inhibition fully antagonized ketotifen (mast stabilizer), granisetron ondansetron antagonists), RP-67,580 (NK 1 antagonist), perivagal capsaicin pretreatment. temporary blockade observed after administration CP-96,345 antagonist) systemically treated capsaicin. generelated peptide antagonist, hCGRP(8–37) did not modify BrX-537A-induced inhibition. Conclusions: 5-HT sensory fibers reaching vagus substance are major components degranulation.
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