Amelioration of neurotoxic effects of HIV envelope protein gp120 by fibroblast growth factor: A strategy for neuroprotection
作者： Ian P. Everall , Gusta Trillo-Pazos , Christopher Bell , Margaret Mallory , Virginia Sanders
关键词: Neurodegeneration 、 HIV envelope protein 、 Immunology 、 Growth factor 、 Neurotrophic factors 、 Neuroprotection 、 Context (language use) 、 Neurotoxicity 、 FGF1 、 Biology
摘要: Approximately two thirds of patients with human immunodeficiency virus encephalitis (HIVE) show cognitive impairment and neurodegeneration, while one third are cognitively unimpaired their neuronal populations preserved. Thus, it is possible that these individuals might have the capacity to produce neurotrophic factors capable protecting neurons against deleterious effects HIV. In this context, main objective study was determine whether fibroblast growth factor 1 (FGF1) protective For purpose levels FGF1 immunoreactivity were determined in frontal cortex 35 AIDS cases subdivided into 4 groups according presence or absence HIVE neurodegeneration. without both mild moderate FGFI observed pyramidal neurons, but significiantly elevated. contrast, neurodegeneration showed low immunoreactivity. Furthermore, studies primary cultures treated HIV envelope protein-gp120 gpl20 neurotoxicity a dose-dependent manner. Taken together, results support notion upregulation certain factors, such as FGF1, protect central nervous system from neurotoxic
core.ac.uk
oup.com
sci-hub.se 参考文章(56)
DA Peterson, CA Lucidi-Phillipi, DP Murphy, J Ray, FH Gage, Fibroblast growth factor-2 protects entorhinal layer II glutamatergic neurons from axotomy-induced death The Journal of Neuroscience. ,vol. 16, pp. 886- 898 ,(1996) , 10.1523/JNEUROSCI.16-03-00886.1996
Peter Klint, Lena Claesson-Welsh, Signal transduction by fibroblast growth factor receptors. Frontiers in Bioscience. ,vol. 4, pp. 165- ,(1999) , 10.2741/KLINT
L.A Boven, J Middel, P Portegies, J Verhoef, G.H Jansen, H.S.L.M Nottet, Overexpression of nerve growth factor and basic fibroblast growth factor in AIDS dementia complex. Journal of Neuroimmunology. ,vol. 97, pp. 154- 162 ,(1999) , 10.1016/S0165-5728(99)00044-2
IAN EVERALL, PHILIP LUTHERT, PETER LANTOS, A review of neuronal damage in human immunodeficiency virus infection: its assessment, possible mechanism and relationship to dementia. Journal of Neuropathology and Experimental Neurology. ,vol. 52, pp. 561- 566 ,(1993) , 10.1097/00005072-199311000-00002
P.Ann Eccleston, Donald H. Silberberg, Fibroblast growth factor is a mitogen for oligodendrocytes in vitro Developmental Brain Research. ,vol. 21, pp. 315- 318 ,(1985) , 10.1016/0165-3806(85)90221-4
Sanjay B Maggirwar, Ning Tong, Servio Ramirez, Harris A Gelbard, Stephen Dewhurst, HIV-1 tat-mediated activation of glycogen synthase kinase-3β contributes to tat-mediated neurotoxicity Journal of Neurochemistry. ,vol. 73, pp. 578- 586 ,(2002) , 10.1046/J.1471-4159.1999.0730578.X
Bernhard H.J. Juurlink, Leif Hertz, Ischemia-induced death of astrocytes and neurons in primary culture: pitfalls in quantifying neuronal cell death. Developmental Brain Research. ,vol. 71, pp. 239- 246 ,(1993) , 10.1016/0165-3806(93)90175-A
Sarah A. Howard, Ann Y. Nakayama, Sheila M. Brooke, Robert M. Sapolsky, Glucocorticoid Modulation of gp120-Induced Effects on Calcium-Dependent Degenerative Events in Primary Hippocampal and Cortical Cultures Experimental Neurology. ,vol. 158, pp. 164- 170 ,(1999) , 10.1006/EXNR.1999.7080
Flore Renaud, Sophie Desset, Lisa Oliver, Guillermo Gimenez-Gallego, Emmanuel Van Obberghen, Yves Courtois, Maryvonne Laurent, The Neurotrophic Activity of Fibroblast Growth Factor 1 (FGF1) Depends on Endogenous FGF1 Expression and Is Independent of the Mitogen-activated Protein Kinase Cascade Pathway Journal of Biological Chemistry. ,vol. 271, pp. 2801- 2811 ,(1996) , 10.1074/JBC.271.5.2801
Felix P. Exkenstien, Fibrolast growth factors in the nervous system Journal of Neurobiology. ,vol. 25, pp. 1467- 1480 ,(1994) , 10.1002/NEU.480251112