Expression of stromal cell-derived factor 1α protein in HIV encephalitis
作者： Dianne Langford , Virginia J. Sanders , Margaret Mallory , Markus Kaul , Eliezer Masliah
DOI: 10.1016/S0165-5728(02)00068-1
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摘要: Abstract Analysis of the patterns stromal cell-derived factor 1α (SDF-1α) expression in brains from HIV-positive patients suggests that neuronal cells, SDF-1α might play a role neuroprotection and neurite extension response to HIV infection. In all cases analyzed, immunoreactivity was primarily present astroglial cells. Patients with encephalitis (HIVE) showed intense somato-dendritic immunoreactivity, while HIVE negative neurodegeneration had significant decrease immunoreactivity. Neuronal cells treated displayed increased outgrowth. Similarly, neurons HIV-Tat, which induced expression, also Tat-mediated outgrowth blocked by anti-SDF-1α antibody. These results suggest may AIDS patients.
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sci-hub.se 参考文章(55)
Ian P. Everall, Gusta Trillo-Pazos, Christopher Bell, Margaret Mallory, Virginia Sanders, Eliezer Masliah, Amelioration of neurotoxic effects of HIV envelope protein gp120 by fibroblast growth factor: A strategy for neuroprotection Journal of Neuropathology and Experimental Neurology. ,vol. 60, pp. 293- 301 ,(2001) , 10.1093/JNEN/60.3.293
Carrie M. McManus, Karen Weidenheim, Scott E. Woodman, Jeranil Nunez, Joseph Hesselgesser, Avindra Nath, Joan W. Berman, Chemokine and Chemokine-Receptor Expression in Human Glial Elements: Induction by the HIV Protein, Tat, and Chemokine Autoregulation American Journal of Pathology. ,vol. 156, pp. 1441- 1453 ,(2000) , 10.1016/S0002-9440(10)65013-4
Philip M. Murphy, Viral exploitation and subversion of the immune system through chemokine mimicry Nature Immunology. ,vol. 2, pp. 116- 122 ,(2001) , 10.1038/84214
Paola Bezzi, Maria Domercq, Liliana Brambilla, Rossella Galli, Dominique Schols, Erik De Clercq, Angelo Vescovi, Giacinto Bagetta, George Kollias, Jacopo Meldolesi, Andrea Volterra, CXCR4-activated astrocyte glutamate release via TNFα: amplification by microglia triggers neurotoxicity Nature Neuroscience. ,vol. 4, pp. 702- 710 ,(2001) , 10.1038/89490
James Hoxie, Dennis Taub, Joseph Hesselgesser, Lawrence F. Brass, Michael Greenberg, Richard Horuk, Meina Liang, Michael J. Orsini, Identification and Characterization of the CXCR4 Chemokine Receptor in Human T Cell Lines: Ligand Binding, Biological Activity, and HIV-1 Infectivity Journal of Immunology. ,vol. 160, pp. 877- 883 ,(1998)
James A. Hoxie, Ehud Lavi, Michael O'Connor, Michael O'Connor, Anthony M. Ulrich, Francisco González-Scarano, Julie M. Strizki, Qian Wang, Li Fu, Wei Zhang, CXCR-4 (fusin), a co-receptor for the type 1 human immunodeficiency virus (HIV-1), is expressed in the human brain in a variety of cell types, including microglia and neurons American Journal of Pathology. ,vol. 151, pp. 1035- 1042 ,(1997)
Ning Tong, Seth W. Perry, Qing Zhang, Harold J. James, Huang Guo, Andrew Brooks, Harshawardhan Bal, Sandra A. Kinnear, Steven Fine, Leon G. Epstein, Daniel Dairaghi, Thomas J. Schall, Howard E. Gendelman, Stephen Dewhurst, Leroy R. Sharer, Harris A. Gelbard, Neuronal Fractalkine Expression in HIV-1 Encephalitis: Roles for Macrophage Recruitment and Neuroprotection in the Central Nervous System The Journal of Immunology. ,vol. 164, pp. 1333- 1339 ,(2000) , 10.4049/JIMMUNOL.164.3.1333
A Björndal, H Deng, M Jansson, J R Fiore, C Colognesi, A Karlsson, J Albert, G Scarlatti, D R Littman, E M Fenyö, Coreceptor usage of primary human immunodeficiency virus type 1 isolates varies according to biological phenotype. Journal of Virology. ,vol. 71, pp. 7478- 7487 ,(1997) , 10.1128/JVI.71.10.7478-7487.1997
A. Mhashilkar, U. De Girolami, W. Marasco, C. Keohane, J. Bell, F. Gray, B. Shi, A. V. Vallat, D. Gabuzda, T. W. Smith, J. He, Localization of HIV-1 co-receptors CCR5 and CXCR4 in the brain of children with AIDS. American Journal of Pathology. ,vol. 152, pp. 167- 178 ,(1998)
Robert K. Heaton, Igor Grant, Nelson Butters, Desireé A. White, Donald Kirson, J. Hampton Atkinson, J. Allen McCutchan, Michael J. Taylor, Mark D. Kelly, Ronald J. Ellis, Tanya Wolfson, Robert Velin, Thomas D. Marcotte, John R. Hesselink, Terry L. Jernigan, James Chandler, Mark Wallace, Ian Abramson, , The HNRC 500-Neuropsychology of Hiv infection at different disease stages Journal of The International Neuropsychological Society. ,vol. 1, pp. 231- 251 ,(1995) , 10.1017/S1355617700000230