The Role of Antigen-Antibody Complexes in Mediating Immunologic Unresponsiveness in the Chicken

摘要: A significant suppression of an adoptive secondary response to either BSA or sheep red blood cells (SRBC) resulted when chicken spleen were incubated with BSA-antibody (Ab) complexes formed in antigen excess (molar ratio Ag1Ab1.1). Serum from 14-day old birds rendered unresponsive at hatching large doses also produced suppression. In addition the vitro SRBC was suppressed by above treatment. Complexes equivalence had no effect on subsequent responses primed enhancement. The fact that both homologous and heterologous inhibited could indicate via a common pathway.