Regulatory roles of cyclin dependent kinase phosphorylation in cell cycle control

作者: Daniel J Lew , Sally Kornbluth

DOI: 10.1016/S0955-0674(96)80080-9

关键词: Cyclin ACDK-activating kinaseProtein phosphorylationBiologyCyclin-dependent kinase 1Cyclin-dependent kinase 6Restriction pointBiochemistryPolo-like kinaseCyclin-dependent kinaseCell biology

摘要: Abstract Cyclins and cyclin-dependent kinases (Cdks) are universal regulators of cell cycle progression in eukaryotic cells. Cdk activity is controlled by phosphorylation at three conserved sites, many the enzymes that act on these sites have now been identified. Although biochemistry CdK relatively well understood, regulatory roles such are, cases, obscure. Recent studies uncovered new unexpected potential roles, prompted re-examination previously assumed phosphorylation.

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