作者: Daniel J Lew , Sally Kornbluth
DOI: 10.1016/S0955-0674(96)80080-9
关键词: Cyclin A 、 CDK-activating kinase 、 Protein phosphorylation 、 Biology 、 Cyclin-dependent kinase 1 、 Cyclin-dependent kinase 6 、 Restriction point 、 Biochemistry 、 Polo-like kinase 、 Cyclin-dependent kinase 、 Cell biology
摘要: Abstract Cyclins and cyclin-dependent kinases (Cdks) are universal regulators of cell cycle progression in eukaryotic cells. Cdk activity is controlled by phosphorylation at three conserved sites, many the enzymes that act on these sites have now been identified. Although biochemistry CdK relatively well understood, regulatory roles such are, cases, obscure. Recent studies uncovered new unexpected potential roles, prompted re-examination previously assumed phosphorylation.