Synthesis of Some Novel Fused Pyrimido[4″,5″:5′,6′]-[1,2,4]triazino[3′,4′:3,4] [1,2,4]triazino[5,6-b]indoles with Expected Anticancer Activity

摘要: Our current goal is the synthesis of polyheterocyclic compounds starting from 3-amino-[1,2,4]triazino[5,6-b]indole 1 and studying their anticancer activity to determine whether increasing size molecules increases or not. 1-Amino[1,2,4]triazino[3′,4′:3,4]-[1,2,4]triazino[5,6-b]indole-2-carbonitrile (4) was prepared by diazotization 3-amino[1,2,4]-triazino[5,6-b]indole followed coupling with malononitrile in basic medium then cyclization under reflux get 4. Also, new fused pyrimido[4″,5″:5′,6′][1,2,4]triazino-[3′,4′:3,4][1,2,4]triazino[5,6-b]indole derivative 6 used obtain polycyclic heterocyclic systems. Confirmation synthesized compounds’ structures carried out using elemental analyses spectral data (IR, 1H-NMR 13C-NMR mass spectra). The some tested against HepG2, HCT-116 MCF-7 cell lines. screening results showed that derivatives display good which more potent than reference drug used. Molecular docking predict binding between prostate cancer 2q7k hormone breast ‎cancer 3hb5 receptors.