Distinct hepatic receptors for low density lipoprotein and apolipoprotein E in humans
作者： J. Hoeg , S. Demosky , R. Gregg , E. Schaefer , H. Brewer
关键词: Very low-density lipoprotein 、 Apolipoprotein C2 、 Blood lipids 、 Apolipoprotein E 、 Endocrinology 、 Lipoprotein 、 Apolipoprotein B 、 Familial hypercholesterolemia 、 Biology 、 Low-density lipoprotein 、 Internal medicine
摘要: Since the liver is a central organ for lipid and lipoprotein synthesis catabolism, hepatic receptors specific apolipoproteins on plasma lipoproteins would be expected to modulate metabolism. The role of low density apolipoprotein E-containing was evaluated in patients with complementary disorders metabolism: abetalipoproteinemia homozygous familial hypercholesterolemia. In addition, membranes from patient hypercholesterolemia were studied compared before after portacaval shunt surgery. results establish that human has B E. Furthermore, human, E are genetically distinct can undergo independent control.
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