Amyloid in familial amyloidosis, Finnish type, is antigenically and structurally related to gelsolin.
作者： G Gallo , J Ghiso , F Prelli , B Frangione , H Somer
DOI:
关键词: Transthyretin 、 Gelsolin 、 Hereditary gelsolin amyloidosis 、 Biochemistry of Alzheimer's disease 、 Biochemistry 、 P3 peptide 、 Protein subunit 、 Amyloid 、 Biology 、 Molecular biology 、 Amyloidosis
摘要: Immunohistochemical studies of six patients with familial amyloidosis, Finnish type, showed that their amyloid deposits did not react polyclonal antibodies against the proteins other, established forms systemic or cerebral amyloidosis. However, strong immunoreactivity was observed rabbit antiserum raised a low molecular weight purified subunit isolated from one patients. This abolished by absorption fraction. The amino terminal sequence protein homologous to gelsolin, an actin-modulating protein, and in tissues reacted monoclonal antibody gelsolin. These show is related previously identified amyloid, including prealbumin (transthyretin) variants, but represents novel amyloidogenic plasma cytoplasmic protein.
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