Oncogenic K-ras promotes early carcinogenesis in the mouse proximal colon.
作者： Shelly R. Calcagno , Shuhua Li , Migdalisel Colon , Pamela A. Kreinest , E. Aubrey Thompson
DOI: 10.1002/IJC.23383
关键词: Azoxymethane 、 Cancer research 、 Transgene 、 Carcinogenesis 、 Pathology 、 Intestinal mucosa 、 Aberrant crypt foci 、 Colorectal cancer 、 Biology 、 Tumor initiation 、 Genetically modified mouse
摘要: … colon carcinogen azoxymethane (AOM). Similar neoplastic changes involving the entire colon are induced in transgenic mice constitutively expressing K‐ras G12D throughout the colon …
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