Monitoring tryptophan metabolism after exposure to hexaconazole and the enantioselective metabolism of hexaconazole in rat hepatocytes in vitro.

作者: Yao Wang , Wentao Zhu , Jing Qiu , Xinru Wang , Ping Zhang

DOI: 10.1016/J.JHAZMAT.2015.04.006

关键词: KynurenineCytotoxicityEnantiomerBiochemistryMetabolismTryptophanToxicityBiologyHexaconazoleIn vitro

摘要: … (−)-hexaconazole enrichment. Using the MTT method, the EC 50 values of rac-hexaconazole, (+)-hexaconazole and (−)-hexaconazole after 12 … metabolism and toxicity of hexaconazole. …

参考文章(46)
S.R. Wagle, W.R. Ingebretsen, [55] Isolation, purification, and metabolic characteristics of rat liver hepatocytes Methods in Enzymology. ,vol. 35, pp. 579- 594 ,(1975) , 10.1016/0076-6879(75)35186-0
Peter Moldéus, Johan Högberg, Sten Orrenius, [4] Isolation and use of liver cells Methods in Enzymology. ,vol. 52, pp. 60- 71 ,(1978) , 10.1016/S0076-6879(78)52006-5
Milton W. Taylor, Gensheng Feng, Relationship between interferon‐γ, indoleamine 2,3‐dioxygenase, and tryptophan catabolism The FASEB Journal. ,vol. 5, pp. 2516- 2522 ,(1991) , 10.1096/FASEBJ.5.11.1907934
Michael S. Denison, Scott R. Nagy, Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals. Annual Review of Pharmacology and Toxicology. ,vol. 43, pp. 309- 334 ,(2003) , 10.1146/ANNUREV.PHARMTOX.43.100901.135828
Kim L. R. Brouwer, Edward L. LeCluyse, Xingrong Liu, Jacqueline I. Lee, Jacqueline I. Lee, Ruth M. Lightfoot, Ruth M. Lightfoot, Kenneth R. Brouwer, Kenneth R. Brouwer, Use of Ca2+ Modulation to Evaluate Biliary Excretion in Sandwich-Cultured Rat Hepatocytes Journal of Pharmacology and Experimental Therapeutics. ,vol. 289, pp. 1592- 1599 ,(1999)
Y. Ozaki, M. P. Edelstein, D. S. Duch, Induction of indoleamine 2,3-dioxygenase: a mechanism of the antitumor activity of interferon gamma Proceedings of the National Academy of Sciences of the United States of America. ,vol. 85, pp. 1242- 1246 ,(1988) , 10.1073/PNAS.85.4.1242
Katja Dettmer, Pavel A. Aronov, Bruce D. Hammock, Mass spectrometry-based metabolomics. Mass Spectrometry Reviews. ,vol. 26, pp. 51- 78 ,(2007) , 10.1002/MAS.20108
Xianai Wu, Ananya Pramanik, Michael W. Duffel, Eugene G. Hrycay, Stelvio M. Bandiera, Hans-Joachim Lehmler, Izabela Kania-Korwel, 2,2',3,3',6,6'-Hexachlorobiphenyl (PCB 136) is Enantioselectively Oxidized to Hydroxylated Metabolites by Rat Liver Microsomes Chemical Research in Toxicology. ,vol. 24, pp. 2249- 2257 ,(2011) , 10.1021/TX200360M
Izabela Kania-Korwel, Hans-Joachim Lehmler, Chlordane and heptachlor are metabolized enantioselectively by rat liver microsomes. Environmental Science & Technology. ,vol. 47, pp. 8913- 8922 ,(2013) , 10.1021/ES401916A