Mutationen des Frizzled-4-Gens
作者： M. Müller , C. Kusserow , U. Orth , U. Klär-Dißars , H. Laqua
DOI: 10.1007/S00347-007-1617-7
关键词: Biology 、 Gynecology
摘要: Hintergrund Die autosomal-dominante (familiare) exsudative Vitreoretinopathie (adEVR) ist eine seltene, genetisch bedingte Erkrankung des retinalen Gefassystems, die in schwer betroffenen Augen zur Blindheit fuhren kann. Eines der Krankheitsgene liegt auf dem Chromosom 11q13–q23 und kodiert fur das „frizzled-4-“ (FZD4-)Protein, an vaskularen Differenzierung beteiligt ist.
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