Antiviral Agents for Non-Human Immunodeficiency Virus Infections

作者: Michael R. Keating

DOI: 10.4065/74.12.1266

关键词: RibavirinFamciclovirRimantadineCytomegalovirus retinitisVirusImmunologyGanciclovirFoscarnetVirologyMedicineCidofovir

摘要: Several new agents for treating viral infections have been developed in recent years. All available are virustatic, inhibiting specific steps the process of replication. No agent is active against nonreplicating or latent viruses. Acyclovir useful treatment genital herpes, herpes simplex encephalitis, mucocutaneous herpetic infection, varicella infection immunosuppressed host, and zoster normal host. It can also be used prevention herpesvirus immunocompromised patients. Ganciclovir indicated cytomegalovirus retinitis patients with acquired immunodeficiency syndrome effective other Famciclovir valacyclovir management varicella-zoster infection. Amantadine rimantadine therapeutically prophylactically influenza A virus Chronic hepatitis B respond to lamivudine therapy, optimal C combination interferon alfa ribavirin. Despite pronounced toxic effects, foscarnet cidofovir antiviral settings.

参考文章(97)
David P. Calfee, Frederick G. Hayden, New approaches to influenza chemotherapy. Neuraminidase inhibitors. Drugs. ,vol. 56, pp. 537- 553 ,(1998) , 10.2165/00003495-199856040-00003
H. H. Balfour, B. Bean, L. Corey, O. L. Laskin, P. McGuirt, J. C. Huff, Y. J. Bryson, J. D. Connor, Therapy of herpes zoster with oral acyclovir The American Journal of Medicine. ,vol. 85, pp. 84- 89 ,(1988)
Frederick G. Hayden, Update on influenza and rhinovirus infections. Advances in Experimental Medicine and Biology. ,vol. 458, pp. 55- 67 ,(1999) , 10.1007/978-1-4615-4743-3_6
K B Frank, J F Chiou, Y C Cheng, Interaction of herpes simplex virus-induced DNA polymerase with 9-(1,3-dihydroxy-2-propoxymethyl)guanine triphosphate. Journal of Biological Chemistry. ,vol. 259, pp. 1566- 1569 ,(1984) , 10.1016/S0021-9258(17)43446-6
D. Derse, Y.C. Cheng, P.A. Furman, M.H. St Clair, G.B. Elion, Inhibition of purified human and herpes simplex virus-induced DNA polymerases by 9-(2-hydroxyethoxymethyl)guanine triphosphate. Effects on primer-template function. Journal of Biological Chemistry. ,vol. 256, pp. 11447- 11451 ,(1981) , 10.1016/S0021-9258(19)68420-6
C. L. Fleming, R. J. Whitley, C. A. Alford, S. J. Soong, A. J. Nahmias, G. G. Galasso, Vidarabine Therapy of Neonatal Herpes Simplex Virus Infection Pediatrics. ,vol. 66, pp. 495- 501 ,(1980)
Robert B. Belshe, Betty Burk, Frances Newman, Richard L. Cerruti, Iain S. Sim, Resistance of Influenza A Virus to Amantadine and Rimantadine: Results of One Decade of Surveillance The Journal of Infectious Diseases. ,vol. 159, pp. 430- 435 ,(1989) , 10.1093/INFDIS/159.3.430
F. Ciampor, C.A. Thompson, S. Grambas, A.J. Hay, Regulation of pH by the M2 protein of influenza A viruses Virus Research. ,vol. 22, pp. 247- 258 ,(1992) , 10.1016/0168-1702(92)90056-F
D Gold, L Corey, Acyclovir prophylaxis for herpes simplex virus infection. Antimicrobial Agents and Chemotherapy. ,vol. 31, pp. 361- 367 ,(1987) , 10.1128/AAC.31.3.361