New helicase-primase inhibitors as drug candidates for the treatment of herpes simplex disease
作者： Gerald Kleymann , Rüdiger Fischer , Ulrich A.K. Betz , Martin Hendrix , Wolfgang Bender
DOI: 10.1038/NM0402-392
关键词: Herpes simplex disease 、 Cold sore 、 Primase 、 Virology 、 Amenamevir 、 Herpes simplex virus 、 Medicine 、 Immunology 、 Drug 、 Mechanism of action 、 Disease 、 General Biochemistry, Genetics and Molecular Biology 、 General Medicine
摘要: … the milestone development in the late 1970s of acyclovir (Zovirax), a nucleosidic inhibitor of … Here we report new inhibitors of the HSV helicase-primase with potent in vitro anti-herpes …
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