Biological cost and compensatory evolution in fusidic acid-resistant Staphylococcus aureus

摘要: Fusidic acid resistance resulting from mutations in elongation factor G (EF-G) of Staphylococcus aureus is associated with fitness costs during growth vivo and vitro. In both environments, these can be partly or fully compensated by the acquisition secondary intragenic mutations. Among clinical isolates S. aureus, fusidic acid-resistant strains have been identified that carry multiple EF-G at positions similar to those shown experimentally cause compensation. This observation suggests fitness-compensatory may an important aspect evolution antibiotic environment, contribute a stabilization resistant bacteria present bacterial population.