Retraction

摘要: Mentally retarded people typically exhibit poor sleep efficiency and reduced nocturnal plasma melatonin levels. The daytime administration of oral to those people, in doses that raise their levels the range, can accelerate onset. We examined ability similar, physiological restore nighttime mentally subjects with deficits. In a double-blind, placebo-controlled study, (n = 20) received, randomized order, placebo two (0.1, 3.0 mg) orally 30 minutes before bedtime for week. Treatments were separated by 1-week washout periods. Sleep data obtained polysomnography on last three nights each treatment period. physiologic dose (0.3 restored (p < 0.0001), acting principally midthird night; it also elevated 0.0008) normal. lowest (0.1 improved sleep.