Administration of melatonin mixed with soft food and liquids for children with neurodevelopmental difficulties.

摘要: It is sometimes necessary for the contents of medication capsules to be mixed with certain foods and drinks because children are not always able swallow capsules. The compatibility short-term stability (6h) melatonin in a variety liquids foodstuffs (water, orange juice, semi-skimmed milk, strawberry yogurt, jam) were analyzed degradation. Extraction from these common administration vehicles an analytical assay drug its potential degradation products developed validated. results showed good recovery low- high-strength all (between 89% minimum 111% maximum). was found stable tested up 6 hours at room temperature (no peak); hence it unlikely compromise Use Melatonin Children Neurodevelopmental Disorders Impaired Sleep trial.